4.6 Editorial Material

White Matter Matters in Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Review Cell Biology

Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function

Jessica L. Fletcher et al.

Summary: Oligodendrocytes play a crucial role in adding myelin sheaths to neurons, supporting axon health, and modulating neuronal function throughout cortical development and adulthood. They also have a lifelong impact on learning and memory, highlighting the importance of myelination in sustaining neural circuits and functions.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Article Neurosciences

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease

Jing-Fei Chen et al.

Summary: The study found a significant increase in new myelin formation rate in the APP/PS1 mouse model of Alzheimer's disease, despite a decrease in overall myelination levels in the cortex and hippocampus. Enhancing myelin renewal through genetic or pharmacological methods improved cognitive performance in memory-related tasks.

NEURON (2021)

Review Neurosciences

Myelin Plasticity and Nervous System Function

Michelle Monje

ANNUAL REVIEW OF NEUROSCIENCE, VOL 41 (2018)

Review Neurosciences

White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes

Sara E. Nasrabady et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Review Geriatrics & Gerontology

Alzheimer's disease as homeostatic responses to age-related myelin breakdown

George Bartzokis

NEUROBIOLOGY OF AGING (2011)