Journal
MATERIALS
Volume 15, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ma15010234
Keywords
silver nanoparticles; hyaluronic acid; biopolymers; nanocomposites; polysaccharides
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Funding
- Ministry of Science & Higher Education (MNiSW) through Jagiellonian University Medical College [N41/DBS/000431, N41/DBS/000597]
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In recent years, there have been rapid developments in novel biomaterials, resulting in the synthesis of complexes involving nanosilver and hyaluronic acid. These complexes possess antimicrobial, anti-inflammatory, anti-angiogenic, and tissue repair properties, making them potentially useful for chronic wound treatment, analgesic therapy, anticancer strategies, and chemical substance detection.
For the last years scientific community has witnessed a rapid development of novel types of biomaterials, which properties made them applicable in numerous fields of medicine. Although nanosilver, well-known for its antimicrobial, anti-angiogenic, anti-inflammatory and anticancer activities, as well as hyaluronic acid, a natural polysaccharide playing a vital role in the modulation of tissue repair, signal transduction, angiogenesis, cell motility and cancer metastasis, are both thoroughly described in the literature, their complexes are still a novel topic. In this review we introduce the most recent research about the synthesis, properties, and potential applications of HA-nanosilver composites. We also make an attempt to explain the variety of mechanisms involved in their action. Finally, we present biocompatible and biodegradable complexes with bactericidal activity and low cytotoxicity, which properties suggest their suitability for the prophylaxis and therapy of chronic wounds, as well as analgetic therapies, anticancer strategies and the detection of chemical substances and malignant cells. Cited studies reveal that the usage of hyaluronic acid-silver nanocomposites appears to be efficient and safe in clinical practice.
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