Journal
MATERIALS
Volume 15, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ma15020569
Keywords
scintillating nanoparticle; GdF3; Tb3+; organic photosensitizer; Rose Bengal; X-ray induced photodynamic therapy; computer tomography
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Funding
- Russian Science Foundation [19-15-00305]
- Russian Science Foundation [19-15-00305] Funding Source: Russian Science Foundation
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In this study, a nanocomposite for X-ray-induced photodynamic therapy and computed tomography was developed using PEG-capped GdF3:Tb3+ scintillating nanoparticles conjugated with Rose Bengal. The synthesized nanoparticles had an elongated spindle-like clustered morphology with an orthorhombic structure, and the presence of PEG coating and Rose Bengal conjugates was confirmed. Fluorescent resonant energy transfer between scintillating nanoparticles and Rose Bengal was efficiently detected upon X-ray irradiation of the nanocomposite solution.
Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF3:Tb3+ scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF3:Tb3+ nanoparticles were synthesized by a facile and cost-effective wet chemical precipitation method. All synthesized nanoparticles had an elongated spindle-like clustered morphology with an orthorhombic structure. The structure, particle size, and morphology were determined by transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analysis. The presence of a polyethylene glycol (PEG) coating and Rose Bengal conjugates was proved by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and ultraviolet-visible (UV-vis) analysis. Upon X-ray irradiation of the colloidal PEG-capped GdF3:Tb3+-Rose Bengal nanocomposite solution, an efficient fluorescent resonant energy transfer between scintillating nanoparticles and Rose Bengal was detected. The biodistribution of the synthesized nanoparticles in mice after intravenous administration was studied by in vivo CT imaging.
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