Journal
JOURNAL OF DIABETES INVESTIGATION
Volume 13, Issue 2, Pages 213-226Publisher
WILEY
DOI: 10.1111/jdi.13725
Keywords
Adaptive immune system; Diabetic kidney disease; Inflammation
Categories
Funding
- Chinese Scholarship Council [201806230303]
Ask authors/readers for more resources
Diabetic kidney disease (DKD) is a prevalent complication of diabetes and a leading cause of end-stage kidney disease. Inflammation plays a crucial role in the progression of DKD, with the adaptive immune system potentially contributing to the disease development. Targeting the adaptive immune system, specifically T cells, may have therapeutic benefits in preventing the progression of DKD.
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon-gamma and tumor necrosis factor-alpha, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available