4.7 Review

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Journal

DRUG DESIGN DEVELOPMENT AND THERAPY
Volume 15, Issue -, Pages 4503-4525

Publisher

DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S327378

Keywords

anti-inflammatory; osteoarthritis; psoriasis; atherosclerotic; pharmacokinetics; prodrug

Funding

  1. National special fund for intangible cultural heritage prtection by ministry of culture and tourism of the people's Republic of China
  2. Key R&D projects by Science & Technology Department of Sichuan Province [20ZDYF1642]
  3. Xinglin Scholar Research Premotion Project of Chengdu University of TCM [BSH2019026]
  4. Open Research Fund of Chengdu University of TCM State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China [2020QNJS005]
  5. China Postdoctoral Science Foundation [2020M673567XB]

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Curcumin, a natural compound, shows great potential in disease treatment with its significant anti-inflammatory effect. It has been proven to effectively improve symptoms of inflammatory diseases, making it a promising candidate for related disease treatments.
Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. Inflammation is a complex and pervasive physiological and pathological process. The physiological and pathological mechanisms of inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 and other research focus diseases are not clear yet, and they are considered to be related to inflammation. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and the latest research results on the improvement of curcumin pharmacokinetics. It is beneficial to the further study of curcumin and provides new ideas and insights for the development of curcumin anti-inflammatory preparations.

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