4.7 Article

Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Rheumatoid pannus presenting as a large epidural mass in the subaxial cervical spine: A case report

N. K. Leclair et al.

Summary: This study presents a case of rapid quadriparesis due to spinal cord compression caused by inflammatory pannus formation in the cervical spine of a patient with rheumatoid arthritis. Surgical treatment led to recovery of strength in all extremities.

NEUROCHIRURGIE (2022)

Article Rheumatology

Renin-angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis

Nayara Felicidade Tomaz Braz et al.

Summary: The study compared serum levels of RAS components in women with RA and healthy females, finding differences and associations with subclinical atherosclerosis. The imbalance of RAS axes may be related to cardiovascular risk and disease activity in rheumatoid arthritis patients. Ultrasonography of carotid arteries can help identify early atherosclerotic disease in RA patients.

MODERN RHEUMATOLOGY (2021)

Article Biochemical Research Methods

MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm

Qifeng Bai et al.

Summary: Deep learning has been successfully applied in medicine and two-dimensional ligand design. MolAICal software combines the merits of deep learning model and classical algorithm to generate 3D drugs in the 3D pocket of protein targets, showing great potential in drug design.

BRIEFINGS IN BIOINFORMATICS (2021)

Article Cell Biology

Umbelliferone Ameliorates Complete Freund Adjuvant-Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation

Guofeng Wu et al.

Summary: In this study, umbelliferone was found to have a significant inhibitory effect on the CFA-induced rheumatoid arthritis model, reducing joint swelling and increasing body weight. Additionally, umbelliferone significantly reduced osteoclast numbers by modulating the RANKL/RANK/OPG ratio.

INFLAMMATION (2021)

Article Plant Sciences

Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-KB and Ras/Raf/MEK pathways

Xueshuang Liu et al.

Summary: Licochalcone A demonstrates anti-tumor activity by inhibiting PD-L1 expression and interfering with the interaction between p65 and Ras to regulate the immune response. It also inhibits cell proliferation, promotes cell apoptosis, and potentially suppresses tumor growth.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

Integrated serum pharmacochemistry and network pharmacological analysis used to explore possible anti-rheumatoid arthritis mechanisms of the Shentong-Zhuyu decoction

Lin Wang et al.

Summary: This study identified bioactive compounds and potential mechanisms for a traditional Chinese medicine formula by integrating serum pharmacochemistry and network pharmacology. The results suggested the feasibility of this integrated strategy for studying the therapeutic effects of herbal remedies.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis

Donghao Gan et al.

Summary: Clinical studies have shown that pirfenidone effectively relieves joint pain in rheumatoid arthritis patients. This study investigated the repurposing of pirfenidone for RA treatment and explored its anti-rheumatic mechanisms. Through in vivo and in vitro models, the study suggested that pirfenidone may alleviate pathological changes in RA by inhibiting inflammation and angiogenesis through multiple pathways such as JAK2/STAT3 and Akt.

FRONTIERS IN PHARMACOLOGY (2021)

Review Clinical Neurology

Comparison of Efficacy of Ketoprofen and Ibuprofen in Treating Pain in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Fabiola Atzeni et al.

Summary: A new meta-analysis comparing ketoprofen and ibuprofen in patients with RA found that ketoprofen was more effective in managing RA pain at therapeutic doses. There were no significant differences between the two drugs in terms of tolerability or safety based on the studies included in the meta-analysis.

PAIN AND THERAPY (2021)

Review Immunology

The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis

Nora Petrovska et al.

Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease involving a multistep process, with the combination of ACPA and RF increasing the risk of RA development. Early detection of ACPA can predict the onset of RA, and intervention targeting at-risk populations in different stages of RA may be crucial in preventing the disease.

AUTOIMMUNITY REVIEWS (2021)

Article Chemistry, Applied

Dendrobium huoshanense stem polysaccharide ameliorates rheumatoid arthritis in mice via inhibition of inflammatory signaling pathways

Zhen-Zi Shang et al.

Summary: The study showed that Dendrobium huoshanense stem polysaccharide has a beneficial effect on rheumatoid arthritis in mice, alleviating symptoms and rebalancing immune cells while inhibiting inflammatory pathways.

CARBOHYDRATE POLYMERS (2021)

Article Gastroenterology & Hepatology

Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases

Joseph Meserve et al.

Summary: The study found that exposure to immunosuppressive or biologic agents around conception in expectant fathers with immune-mediated inflammatory diseases (IMIDs) did not increase the risk of adverse birth outcomes, including major congenital malformations, preterm birth, and low birth weight.

GASTROENTEROLOGY (2021)

Review Plant Sciences

Recent advances in chemistry and bioactivity of Sargentodoxa cuneata

Wen Zhang et al.

Summary: The genus Sargentodoxa, with its only species Sargentodoxa cuneata, is widely used in traditional Chinese medicine for various ailments, with pharmacological studies showing a range of activities. This review aims to provide a scientific basis for its traditional uses and support its development for new drug applications by summarizing its distribution, traditional uses, chemical constituents, and pharmacological activities.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Plant Sciences

A review on traditional usages, chemical constituents and pharmacological activities of periploca forrestii schltr

Lei Chen et al.

Summary: Periploca forrestii, a classical medicinal plant in Miao medicine, has been used traditionally in the treatment of rheumatoid arthritis and traumatic injury. Modern pharmacological studies have shown its diverse bioactivities, but further research is needed to understand its mechanism of action and long-term effects.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Cell Biology

Protectin DX restores Treg/Th17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a

Shengwei Jin et al.

Summary: Protectin DX (PDX) was found to effectively ameliorate the progression of collagen-induced arthritis by restoring Treg/T(h)17 cell balance, and this effect was mediated by inhibiting the NLRP3 inflammasome pathway via miR-20a.

CELL DEATH & DISEASE (2021)

Review Pharmacology & Pharmacy

A systematic review on traditional medicine Toddalia asiatica (L.) Lam.: Chemistry and medicinal potential

Zhi Zeng et al.

Summary: Toddalia asiatica, a traditional folk medicine in China, contains mainly coumarins and alkaloids with pharmacological effects including anti-inflammatory, hemostatic, anti-tumor properties. It is clinically effective in treating rheumatism, pain, wound bleeding, and bruises.

SAUDI PHARMACEUTICAL JOURNAL (2021)

Article Multidisciplinary Sciences

S100A11 (calgizzarin) is released via NETosis in rheumatoid arthritis (RA) and stimulates IL-6 and TNF secretion by neutrophils

Adela Navratilova et al.

Summary: This study demonstrates, for the first time, that the release of S100A11 is dependent on NETosis and that extracellular S100A11 augments the inflammatory response by inducing pro-inflammatory cytokines in neutrophils.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

FCER1G and PTGS2 Serve as Potential Diagnostic Biomarkers of Acute Myocardial Infarction Based on Integrated Bioinformatics Analyses

Shengjue Xiao et al.

Summary: This study identified potential diagnostic biomarkers and mechanisms for acute myocardial infarction (AMI) through gene expression analysis, highlighting specific genes involved in inflammatory responses and signaling pathways. Additionally, the study identified hub genes and evaluated the diagnostic value of FCER1G and PTGS2, showing promising results for their use in diagnosing AMI. Furthermore, the study also revealed miRNAs that target PTGS2 in the progression of AMI.

DNA AND CELL BIOLOGY (2021)

Article Neurosciences

Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells

Mayuko Sugimoto et al.

Summary: Formononetin protects against H2O2-induced neuroblastoma cell death by reducing ROS levels and enhancing antioxidant gene expression through the activation of the PI3K/Akt-Nrf2 signaling pathway. Additionally, formononetin suppresses apoptosis by inhibiting MAPK phosphorylation in SH-SY5Y cells, suggesting its potential as a therapeutic agent for neurodegenerative diseases.

NEUROTOXICOLOGY (2021)

Article Multidisciplinary Sciences

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop

Jiajun Yap et al.

Summary: The study identified a novel group of oncogenic BRAF mutants with stabilized R-spines, leading to strong resistance to RAF inhibitors, which is not due to dimer affinity but rather stability of the R-spine.

SCIENCE ADVANCES (2021)

Article Medicine, Research & Experimental

MMP2 and TLRs modulate immune responses in the tumor microenvironment

Luciana R. Muniz-Bongers et al.

Summary: The study revealed that MMP2 plays a promoting role in melanoma tumor growth by reducing cytolytic cells and increasing M2 macrophages. On the other hand, knockdown of MMP2 slows tumor growth and enhances T cell proliferation and NK cell recruitment. These effects of MMP2 are mediated through dysfunctional DC-T cell cross-talk.

JCI INSIGHT (2021)

Article Chemistry, Medicinal

Ipso-Substitution in Derivatives of the Quinoline Alkaloid Skimmianine

M. A. Eshonov et al.

Summary: The oxidation of the alkaloid skimmianine generated a formyl derivative, which reacted with homoveratrylamine to form a specific product with a unique structure. In acidic solution, the formyl group in the product stimulated further chemical reaction to produce the final product.

CHEMISTRY OF NATURAL COMPOUNDS (2021)

Review Pharmacology & Pharmacy

Current trends in theranostics for rheumatoid arthritis

Yamini Madav et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Multidisciplinary Sciences

Proteogenomic analysis of pitaya reveals cold stress-related molecular signature

Junliang Zhou et al.

PEERJ (2020)

Article Environmental Sciences

Quantifying spatial morphology and connectivity of urban heat islands in a megacity: A radius approach

Jian Peng et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Biochemistry & Molecular Biology

Effect of Angiotensin II on Bone Erosion and Systemic Bone Loss in Mice with Tumor Necrosis Factor-Mediated Arthritis

Takahiko Akagi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, General & Internal

Rheumatoid Arthritis and CLOVES Syndrome: A Tricky Diagnosis

Laura Damian et al.

DIAGNOSTICS (2020)

Article Pharmacology & Pharmacy

A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

Yasmin Abo-zeid et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Editorial Material Medicine, General & Internal

Novel DMARD monotherapy in rheumatoid arthritis

Anna Molto et al.

LANCET (2019)

Article Clinical Neurology

Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis

Yuanyuan Gong et al.

PAIN RESEARCH & MANAGEMENT (2019)

Article Biochemistry & Molecular Biology

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

Kai Liu et al.

BIOSCIENCE REPORTS (2019)

Article Integrative & Complementary Medicine

Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway

Huan Chen et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Article Cell Biology

Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1α

Zhirong Jia et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Medicine, Research & Experimental

Histological Evaluation of Lumbar Spine Changes in Rats with Collagen-induced Arthritis

Tokumitsu Mihara et al.

YONAGO ACTA MEDICA (2018)

Article Biochemistry & Molecular Biology

YaTCM: Yet another Traditional Chinese Medicine Database for Drug Discovery

Baiqing Li et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2018)

Review Rheumatology

Immunometabolism in early and late stages of rheumatoid arthritis

Cornelia M. Weyand et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Article Cell Biology

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

Corinna Wehmeyer et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Medicine, Research & Experimental

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

Hui-fang Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Chemistry, Multidisciplinary

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Jinlong Ru et al.

JOURNAL OF CHEMINFORMATICS (2014)