Journal
CANCER DISCOVERY
Volume 12, Issue 2, Pages 331-355Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-21-1094
Keywords
-
Categories
Funding
- German Childhood Cancer Foundation [DKS 2015.01, DKS 2017.01, DKS2019.13]
- BMBF ADDRess grant [01GM1909]
- Everest Centre for Low-grade Paediatric Brain Tumours (The Brain Tumour Charity, UK) [GN-000382]
- Low Grade Astrocytoma Fund (PLGA Fund) at the Pediatric Brain Tumor Foundation (PBTF)
- Deutsche Forschungsgemeinschaft (DFG) [404521405]
- European Union [668596]
- Ministry of Health
- 5 x 1000 funds RC2021-IRCCS Ospedale bambino Gesu
- Marjorie K. Harmer Endowment for Research in Padiatric Pathology
- University of Pittsburgh School of Medicine
- NIH [NCI R01CA143167]
- Children with Cancer UK
- Great Ormond Street Hospital Children's Charity
- Olivia Hodson Cancer Fund
- Cancer Research UK
- National Institute of Health Research
- UNITE Glioblastoma
- H2020 Societal Challenges Programme [668596] Funding Source: H2020 Societal Challenges Programme
Ask authors/readers for more resources
Pediatric tumors, although uncommon, are the leading cause of cancer-related death in childhood. The development of the first WHO Classification of Pediatric Tumors recognizes the unique characteristics and origin of these tumors, incorporating morphology, IHC, and molecular characteristics. The classification provides a comprehensive understanding of pediatric tumor types, with a special emphasis on blastomas.
Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO ) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on blastomas, which variably recapitulate the morphologic maturation of organs from which they originate. Significance: In this review , we briefly summarize the main features and updates of each chapter of the inaugural WHO Classification of Pediatric Tumors, including its rapid transition from a mostly microscopic into a molecularly driven classification systematically taking recent discoveries in pediatric tumor genomics into account.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available