Journal
BMC PREGNANCY AND CHILDBIRTH
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12884-021-04217-2
Keywords
Low-dose aspirin; Twin pregnancy; Preeclampsia; Preterm birth; Fetal growth restriction; Postpartum hemorrhage
Categories
Funding
- National Key Research and Development Program of China [2018YFC1002900]
- National Natural Science Foundation of China [81520108013, 81771613, 81671488, 81871189, 82071675]
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The study found that the use of low-dose aspirin in twin pregnancies significantly reduced the risk of preeclampsia and preterm birth, with possible benefits in lowering the rate of small for gestational age babies. Furthermore, the use of low-dose aspirin did not increase the risk of postpartum hemorrhage.
Background: Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Methods: This study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded. Results: LDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24-0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29-0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55-1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35-2.26). Conclusions: Treatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage.
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