4.6 Article

Design and synthesis of nano Cu/chitosan-starch bio-composite for the treatment of human thyroid carcinoma

Journal

ARABIAN JOURNAL OF CHEMISTRY
Volume 15, Issue 1, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.arabjc.2021.103465

Keywords

Chitosan-starch; Copper nanoparticles; Human thyroid carcinoma; Antioxidant

Funding

  1. Deanship of Scientific Research at King Khalid University [R.G.P2/108/41]
  2. ministry of education [IFPKKU-2020/11]

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This study successfully synthesized nontoxic and stable copper nanoparticles using chitosan/starch hydrogel, which showed significant anti-thyroid carcinoma effects and strong antioxidant activity.
In this study we report the green synthesis of nontoxic and stable Cu nanoparticles (NP) using chitosan/starch hydrogel with reducing/capping ability without using any harsh reducing agents. Starch was used as a reducing agent for the synthesis of Cu NPs that was further stabilized by chitosan polymers. The in situ prepared Cu NPs/CS-Starch bio-composite were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD), UV-Vis, TGA and Inductively Coupled Plasma-Optical Emission Spectroscopic (ICP-OES) study. It has been established that Cu NPs/CSStarch bio-composite have a spherical shape with a mean diameter from 5 to 7 nm. Cell viability of Cu NPs/CS-Starch bio-composite was very low against common human thyroid carcinoma cell lines i.e. TPC1, BCPAP and FTC133 without any cytotoxicity on normal cell line. The best antihuman thyroid carcinoma effects of Cu NPs/CS-Starch bio-composite was observed against the TPC1 cell line. For investigating the antioxidant properties of Cu NPs/CS-Starch bio-composite, the DPPH assay was used in the presence of butylated hydroxytoluene as the positive control. Cu NPs/CS-Starch bio-composite inhibited half of the DPPH molecules in the concentration of 207 mg/mL. The antioxidant activity of Cu NPs/CS-Starch bio-composite is significantly related to its anti-human thyroid carcinoma potentials. Based on to the above findings, the Cu NPs/CSStarch bio-composite could be administrated for the treatment of several types of human thyroid carcinoma in humans. (c) 2021 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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