Regio- and Stereoselective Diarylation of 1,3-Dienes via Ni/Cr Cocatalysis

Through the formation of the thermodynamically favored Cr(III)-O bond, the Nozaki-Hiyama-Kishi reaction has been widely applied in the functionalization of carbonyl compounds with the help of Ni catalysis. Herein, a divergent regio- and stereoselective diarylation of dienes has been developed under Ni/Cr cocatalysis without the inherent driving force for the formation of polar metal alkoxides. Preliminary experimental studies have been conducted to elucidate the key roles of Ni, Cr, and redox-active bis(imino)pyridine (PDI) ligands. The proposed mechanism suggests that the newly formed C-C bond of this diarylation was created by organonickel species instead of organochromium species.

Automated summary

A divergent regio- and stereoselective diarylation of dienes has been developed under Ni/Cr cocatalysis without the inherent driving force for the formation of polar metal alkoxides. Experimental studies have shown the key roles of Ni, Cr, and redox-active bis(imino)pyridine (PDI) ligands. The proposed mechanism suggests the involvement of organonickel species in the formation of the newly created C-C bond.