Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ER alpha) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ER alpha KO mice demonstrates that the hepatic ER alpha, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ER alpha might be a valuable target for dietary treatments for the post-menopause. Menopause is associated with metabolic changes and an increased risk of a number of chronic diseases. Here, the authors show in a mouse model of menopause that an amino acid-enriched diet rescues liver lipid metabolism and prevents weight gain in a manner dependent on hepatic ER alpha.

Automated summary

Post-menopausal metabolic changes and potential chronic diseases can be mitigated through a diet rich in specific amino acids that targets hepatic ER alpha, according to a study using a mouse model of menopause. Liver-specific ER alpha plays a key role in controlling lipid metabolism and preventing weight gain in this context.