Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-28100-6
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Funding
- Natural Science Foundation of China [21925203, 21902093, 21733009]
- Program for Youth Sanjin Scholar
- 100 Talent Project of Shanxi Province
- Fund for Shanxi 1331 Project
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A practical one-pot cascade catalysis method was developed by combining Pickering emulsions with continuous flow. The co-localization of catalytically active sub-compartments within droplets of a Pickering emulsion resulted in cell-like microreactors, which showed enhanced catalysis efficiency and controlled kinetics of cascade catalysis.
A continuous flow cascade of multi-step catalytic reactions is a cutting-edge concept to revolutionize stepwise catalytic synthesis yet is still challenging in practical applications. Herein, a method for practical one-pot cascade catalysis is developed by combining Pickering emulsions with continuous flow. Our method involves co-localization of different catalytically active sub-compartments within droplets of a Pickering emulsion yielding cell-like microreactors, which can be packed in a column reactor for continuous flow cascade catalysis. As exemplified by two chemo-enzymatic cascade reactions for the synthesis of chiral cyanohydrins and chiral ester, 5 - 420 fold enhancement in the catalysis efficiency and as high as 99% enantioselectivity were obtained even over a period of 80 - 240 h. The compartmentalization effect and enriching-reactant properties arising from the biomimetic microreactor are theoretically and experimentally identified as the key factors for boosting the catalysis efficiency and for regulating the kinetics of cascade catalysis. A continuous flow cascade of multi-step catalytic reactions would provide significant advantages in faster reaction times, waste reduction, and lowered step-count of syntheses, yet this ideal remains challenging in practical applications. Here the authors describe continuous flow cascade catalysis through co-localization of two catalytically active subcompartments within Pickering emulsion droplets.
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