Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-28087-0
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Funding
- MRC [MR/0059311]
- National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- NIHR Programme Grants for Applied Research [RP-PG-0610-10100]
- South London and Maudsley NHS Foundation Trust Mental Health BRC
- Northumberland Tyne and Wear NHS Foundation Trust
- NHMRC
- NHMRC Project Grant
- Parkinson's NSW Seed Grant 2013
- NHMRC Investigator grant
- NHMRC-ARC Dementia Fellowship
- NHMRC Practitioner Fellowship
- Monument Trust Discovery Award from Parkinson's UK
- MRC Dementias Platform UK
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)
- NIHR Oxford Health BRC
- National Research Foundation of Korea by the Ministry of Education [NRF-2018R1D1A1B07048959]
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre (BRC) in Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University
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A study using a large-scale analysis of structural imaging data in Parkinson's disease patients with visual hallucinations reveals wider cortical involvement and associations with attentional control networks.
Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson's disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes. Visual hallucinations are a prevalent symptom of Parkinson's disease. Here the authors use a structural mega-analysis to show cortical regions and networks involved in visual hallucinations and associations with receptor density maps.
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