Robust hemostatic bandages based on nanoclay electrospun membranes

Rapid, easy and effective haemostasis is needed to reduce the loss of life from traumatic haemorrhage. Here, the authors report on the creation of polymer-nanoclay electrospun membranes and demonstrate haemostatic effects showing superior effects to other clay based haemostats. Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.

Automated summary

This study reports a novel nanoclay electrospun membrane hemostatic material with excellent hemostatic effects and biocompatibility, which is a potential effective hemostat. This material can achieve rapid and effective hemostasis, suitable for prevention and emergency treatment in situations of dangerous bleeding.