Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-27332-2
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Funding
- Japan Society for the Promotion of Science [19H05633, 19K15691]
- Toyota Physical and Chemical Research Institute
- Precise Measurement Technology Promotion Foundation
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2018-04364]
- Canadian Institutes of Health Research (CIHR) [FS-154310]
- National Institutes of Health (NIH) [U01 NS094246, U24 NS109107, F31 NS108593]
- Alberta Parkinson Society Fellowship
- National Natural Science Foundation of China [31870132, 82072237]
- Grants-in-Aid for Scientific Research [19K15691] Funding Source: KAKEN
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L-Lactate, traditionally considered a metabolic waste product, is now recognized as an important intercellular energy currency in mammals. A genetically encoded biosensor called eLACCO1.1 has been developed to enable cellular resolution imaging of extracellular L-lactate in cultured mammalian cells and brain tissue.
L-Lactate, traditionally considered a metabolic waste product, is increasingly recognized as an important intercellular energy currency in mammals. To enable investigations of the emerging roles of intercellular shuttling of L-lactate, we now report an intensiometric green fluorescent genetically encoded biosensor for extracellular L-lactate. This biosensor, designated eLACCO1.1, enables cellular resolution imaging of extracellular L-lactate in cultured mammalian cells and brain tissue.
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