Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-26417-2
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Funding
- National Natural Science Foundation of China [21788102, 81725009, 81971667]
- Key Research and Development Project of Zhejiang Province [2020C03035]
- Fundamental Research Funds for the Zhejiang Provincial Universities [2021XZZX034]
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The study demonstrates the versatility of AIEgens-based imaging-guided surgical operation from small animals to rhesus macaque, supporting the clinical translation of AIEgens. The folic-AIEgen shows strong and stable fluorescence for detecting and surgically removing sentinel lymph nodes, with potential for guiding the precise resection of invisible cancerous metastases in clinical applications.
Most applications of aggregation-induced emission luminogens (AIEgens) have been limited in small animal models. Here, the authors show the versatility of AIEgens-based imaging-guided surgical operation from small animals to rhesus macaque, in support of the clinical translation of AIEgens. During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications.
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