Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-26681-2
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Funding
- Spanish Agencia Estatal de Investigacion (AEI) [SAF2017-89890-R, PCI2019-103400, PID2020-117143RB-I00]
- Xunta de Galicia [ED431C 2017/25]
- European Commission (ERDF)
- Xunta de Galicia (Centro singular de investigacion de Galicia) [ED431G 2019/03]
- EC
- AEI [2018-843332, FJCI-2017-31795, 18/03192]
- ISCIII [COV20/00297]
- ERC-Stg [DYNAP-677786]
- ERC-PoC (TraffikGene) [838002]
- YIG from the HFSP [RGY0066/2017]
- European Research Council (ERC) [838002] Funding Source: European Research Council (ERC)
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1D supramolecular polymers, commonly found in natural and synthetic systems, have been studied for their functional responses. When confined in aqueous compartments, the chemically triggered supramolecular fibrillation of synthetic peptide amphiphiles can induce molecular uptake, fusion, and chemical exchange as functional environmental responses.
One-dimensional (1D) supramolecular polymers are commonly found in natural and synthetic systems to prompt functional responses that capitalise on hierarchical molecular ordering. Despite amphiphilic self-assembly being significantly studied in the context of aqueous encapsulation and autopoiesis, very little is currently known about the physico-chemical consequences and functional role of 1D supramolecular polymerisation confined in aqueous compartments. Here, we describe the different phenomena that resulted from the chemically triggered supramolecular fibrillation of synthetic peptide amphiphiles inside water microdroplets. The confined connection of suitable dormant precursors triggered a physically autocatalysed chemical reaction that resulted in functional environmental responses such as molecular uptake, fusion and chemical exchange. These results demonstrate the potential of minimalistic 1D supramolecular polymerisation to modulate the behaviour of individual aqueous entities with their environment and within communities. One-dimensional (1D) supramolecular polymers are commonly found in natural and synthetic systems but very little is currently known about the physico-chemical consequences and functional role of 1D supramolecular polymerisation confined in aqueous compartments. Here, the authors describe the different phenomena that resulted from the chemically triggered supramolecular fibrillation of synthetic peptide amphiphiles inside water microdroplets.
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