Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-27406-1
Keywords
-
Categories
Funding
- Chinese Scholarship Council (CSC)
- Deutscher Akademischer Austauschdienst (DAAD)
- Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) [EXC 2056, 390715994]
- University of Trieste
- INSTM
- AXA Research Fund
- Spanish Ministry of Science, Innovation and Universities, MICIU [PID2019-108523RB-I00]
- Italian Ministry of Education MIUR [2017PBXPN4]
- Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency [MDM-2017-0720]
- European Research Council [885323]
- Fraunhofer Attract (Fraunhofer-Gesellschaft)
- European Research Council (ERC) [885323] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The authors conducted a detailed concentration analysis of different chiral carbon nanodots to investigate the effects of chirality on protein absorption and cell internalization accurately. They found that carbon nanodots with opposite chirality possess the same major physicochemical properties, but concentration differences can lead to errors in analysis.
Chirality is known to impact the biological activity of materials but concentration differences can often lead to errors in analysis. Here, the authors report on detailed concertation analysis of different chiral carbon nanodots to accurately investigate chiral effects on the protein absorption and cell internalisation. Carbon nanodots with opposite chirality possess the same major physicochemical properties such as optical features, hydrodynamic diameter, and colloidal stability. Here, a detailed analysis about the comparison of the concentration of both carbon nanodots is carried out, putting a threshold to when differences in biological behavior may be related to chirality and may exclude effects based merely on differences in exposure concentrations due to uncertainties in concentration determination. The present study approaches this comparative analysis evaluating two basic biological phenomena, the protein adsorption and cell internalization. We find how a meticulous concentration error estimation enables the evaluation of the differences in biological effects related to chirality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available