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Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia

Journal

ONCOLOGY LETTERS
Volume 23, Issue 1, Pages -

Publisher

SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.13119

Keywords

Let-7 microRNAs; leukemia; tumor therapy; regulatory factors

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The Let-7 family of miRNAs plays a crucial role in various biological processes and is associated with tumor occurrence and prognosis. Let-7 is not only a potential diagnostic and prognostic marker for leukemia, but also a potential therapeutic target.
The lethal-7 (Let-7) family of microRNAs (miRNAs) controls the process of development and differentiation, but is also related to the occurrence of tumors and a poor prognosis of patients with tumors. Thus, a more comprehensive exploration of its functions will provide further insights into these processes, and may promote the diagnosis and treatment of tumors. Leukemia is a type of progressive malignant disease, and its pathogenesis involves a variety of epigenetic factors. Amongst the several related epigenetic factors, the Let-7 miRNAs are an important family of molecules that play a crucial role in maintaining a variety of critical biological processes, including development, differentiation and proliferation. In the present study, the role of Let-7 as a tumor suppressor gene and oncogene is reviewed, and the complex regulatory functions of several Let-7 family members in different subtypes of leukemia are described. The current body of knowledge thus far indicates that Let-7 is not only a potential diagnostic and prognostic marker of leukemia, but also a potential therapeutic target for the treatment of affected patients, with particular potential when targeted by adjuvant treatments alongside traditional treatment to improve their survival rate.

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