4.4 Review

The role of mediator subunit 12 in tumorigenesis and cancer therapeutics

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

A comprehensive analysis of somatic alterations in Chinese ovarian cancer patients

Yingli Zhang et al.

Summary: Ovarian cancer is commonly diagnosed at advanced stages due to subtle symptoms. This study identified common gene mutations and potential biomarkers for Chinese ovarian cancer patients, laying the foundation for future research on diagnosis and targeted therapy.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Yi-Chuan Li et al.

Summary: The study reveals the structure of the Cdk8 kinase module (CKM), showing that Med12 activates Cdk8 by interacting with CycC, while Med13 has a characteristic Argonaute-like bi-lobal architecture. These findings provide insights into the functional and pathological mechanisms of CKM.

SCIENCE ADVANCES (2021)

Article Oncology

Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases

Xue Chao et al.

Summary: The study presented the clinicopathologic and molecular features of MBC-OD, showing it as a highly aggressive breast tumor with osteosarcoma-like morphology and a high incidence of recurrent disease.

BREAST CANCER (2021)

Review Cell Biology

Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseases

Srishti Srivastava et al.

Summary: Transcriptional dysregulation is central to many diseases, with MED12 playing a critical role as a master regulator of the mediator complex involved in transcription. Mutations or differential expression of MED12 are associated with various human disorders and cancers, making it an attractive novel therapeutic target.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Binding patterns and structure-activity relationship of CDK8 inhibitors

Duo Ma et al.

BIOORGANIC CHEMISTRY (2020)

Article Multidisciplinary Sciences

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

Felix Klatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

MED12 somatic mutations encompassing exon 2 associated with benign breast fibroadenomas and not breast carcinoma in Indian women

Mina Darooei et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Min Ju Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Oncology

Notch Signaling in the Tumor Microenvironment

Olivier Meurette et al.

CANCER CELL (2018)

Article Genetics & Heredity

Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women

Ghada M. A. Ajabnoor et al.

FRONTIERS IN GENETICS (2018)

Review Oncology

Notch as a tumour suppressor

Craig S. Nowell et al.

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene

Babajan Banaganapalli et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

Article Oncology

Frequent MED12 mutations in phyllodes tumours of the breast

M. Yoshida et al.

BRITISH JOURNAL OF CANCER (2015)

Article Oncology

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer

Eugenia V. Broude et al.

CURRENT CANCER DRUG TARGETS (2015)

Review Oncology

MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives

Sabrina Croce et al.

EUROPEAN JOURNAL OF CANCER (2015)

Article Pathology

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases

Cedric Chuan Young Ng et al.

JOURNAL OF CLINICAL PATHOLOGY (2015)

Review Cell Biology

The Mediator complex: a central integrator of transcription

Benjamin L. Allen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis

Dazhi Xu et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Lu Wang et al.

SCIENCE ADVANCES (2015)

Article Oncology

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

Panagiotis Ntziachristos et al.

CANCER CELL (2014)

Article Cell Biology

Redefining the modular organization of the core Mediator complex

Xuejuan Wang et al.

CELL RESEARCH (2014)

Article Oncology

MED12 overexpression is a frequent event in castration-resistant prostate cancer

Zaki Shaikhibrahim et al.

ENDOCRINE-RELATED CANCER (2014)

Article Obstetrics & Gynecology

MED12 mutation frequency in unselected sporadic uterine leiomyomas

Hanna-Riikka Heinonen et al.

FERTILITY AND STERILITY (2014)

Article Pathology

MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors

Katherine E. Schwetye et al.

HUMAN PATHOLOGY (2014)

Article Cell Biology

Cyclin C is a haploinsufficient tumour suppressor

Na Li et al.

NATURE CELL BIOLOGY (2014)

Article Genetics & Heredity

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma

Weng Khong Lim et al.

NATURE GENETICS (2014)

Article Genetics & Heredity

Mutations in MED12 Cause X-Linked Ohdo Syndrome

Anneke T. Vulto-van Silfhout et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2013)

Article Biochemistry & Molecular Biology

Punctuated Evolution of Prostate Cancer Genomes

Sylvan C. Baca et al.

Article Biochemistry & Molecular Biology

MED12 exon 2 mutations in histopathological uterine leiomyoma variants

Netta Makinen et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2013)

Article Cell Biology

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours

Akiko Matsubara et al.

HISTOPATHOLOGY (2013)

Article Pathology

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma

Gloria Ravegnini et al.

MODERN PATHOLOGY (2013)

Article Medicine, General & Internal

Genetics and biomarkers in personalisation of lung cancer treatment

Rafael Rosell et al.

LANCET (2013)

Article Medicine, General & Internal

Characterization of Uterine Leiomyomas by Whole-Genome Sequencing

Miika Mehine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Cell Biology

MED12 mutations in human diseases

Hua Wang et al.

PROTEIN & CELL (2013)

Article Oncology

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

K. Kampjarvi et al.

BRITISH JOURNAL OF CANCER (2012)

Article Oncology

Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

Eun Mi Je et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

Article Multidisciplinary Sciences

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah et al.

NATURE (2012)

Article Multidisciplinary Sciences

Sequence analysis of mutations and translocations across breast cancer subtypes

Shantanu Banerji et al.

NATURE (2012)

Article Multidisciplinary Sciences

The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso et al.

NATURE (2012)

Article Genetics & Heredity

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Christopher E. Barbieri et al.

NATURE GENETICS (2012)

Article Multidisciplinary Sciences

MED12 Alterations in Both Human Benign and Malignant Uterine Soft Tissue Tumors

Gaelle Perot et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

Haiying Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Molecular Architecture of the Human Mediator-RNA Polymerase II-TFIIF Assembly

Carrie Bernecky et al.

PLOS BIOLOGY (2011)

Review Endocrinology & Metabolism

The hedgehog/Gli signaling paradigm in prostate cancer

Mengqian Chen et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2011)

Review Oncology

Cistromics of hormone-dependent cancer

Mathieu Lupien et al.

ENDOCRINE-RELATED CANCER (2009)

Article Cell Biology

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

Matthew T. Knuesel et al.

GENES & DEVELOPMENT (2009)

Article Biochemistry & Molecular Biology

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

Matthew T. Knuesel et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Genetics & Heredity

The original Lujan syndrome family has a novel missense mutation (p. N1007S) in the MED12 gene

Charles E. Schwartz et al.

JOURNAL OF MEDICAL GENETICS (2007)

Article Genetics & Heredity

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome

Hiba Risheg et al.

NATURE GENETICS (2007)

Review Biochemistry & Molecular Biology

Mediator modulates Gli3-dependent sonic hedgehog signaling

Haiying Zhou et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Review Biochemistry & Molecular Biology

Mediator and the mechanism of transcriptional activation

RD Kornberg

TRENDS IN BIOCHEMICAL SCIENCES (2005)

Article Biochemistry & Molecular Biology

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator

R Pavri et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

Ras induces mediator complex exchange on C/EBPβ

XM Mo et al.

MOLECULAR CELL (2004)