4.5 Review

Development of Delivery Systems for Local Administration of Cytokines/Cytokine Gene-Directed Therapeutics: Modern Oncologic Implications

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer

Rebeca Gonzalez-Pastor et al.

Summary: Ovarian cancer presents challenges in treatment, but new therapies based on oncolytic adenoviruses show promise in improving outcomes, especially when used in combination with immunotherapies.

CANCER GENE THERAPY (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Medicine, General & Internal

Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas

G. K. Friedman et al.

Summary: The study conducted a phase 1 trial of G207 in children and adolescents with recurrent or progressive supratentorial brain tumors, showing an acceptable adverse-event profile and evidence of responses. G207 was able to convert immunologically cold tumors to hot.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study

Premal H. Thaker et al.

Summary: GEN-1 combined with standard NACT was shown to be safe, effective, and impactful on the tumor microenvironment in patients with advanced epithelial ovarian cancer.

CLINICAL CANCER RESEARCH (2021)

Review Immunology

Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?

Hillard M. Lazarus et al.

Summary: Sargramostim accelerates hematologic recovery in diverse clinical settings and enhances anti-cancer responses with a favorable safety profile. Uses other than in hematologic recovery are less-well studied; more data are needed on immune-enhancing benefits.

FRONTIERS IN IMMUNOLOGY (2021)

Review Chemistry, Medicinal

Clinical Application of Cytokines in Cancer Immunotherapy

Yi Qiu et al.

Summary: Cytokines play crucial roles in the immune response to cancer and hold promise for precise cancer treatment. Clinical studies have shown progress in the use of cytokine-based drugs for cancer therapy, focusing on improving delivery efficiency, stability, biocompatibility, and availability.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Medicine, Research & Experimental

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander Huyghe et al.

EMBO MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

Cytokines in oncolytic virotherapy

Jonathan G. Pol et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Review Oncology

Cytokines in clinical cancer immunotherapy

Pedro Berraondo et al.

BRITISH JOURNAL OF CANCER (2019)

Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update

Aaron C. Anselmo et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

Article Pharmacology & Pharmacy

Impact of silver, gold, and iron oxide nanoparticles on cellular response to tumor necrosis factor

Kamil Brzoska et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Oncology

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Riikka Havunen et al.

MOLECULAR THERAPY-ONCOLYTICS (2018)

Article Nanoscience & Nanotechnology

Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice

Lunmei Tan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Oncology

On-Body Injector An administration device for pegfilgrastim

Linda J. Mahler et al.

CLINICAL JOURNAL OF ONCOLOGY NURSING (2017)

Review Oncology

Intralesional treatment of metastatic melanoma: a review of therapeutic options

Benjamin Weide et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

Article Pharmacology & Pharmacy

Talimogene Laherparepvec: First Global Approval

Sarah L. Greig

DRUGS (2016)

Review Pharmacology & Pharmacy

PEGylation in anti-cancer therapy: An overview

Prajna Mishra et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity

Chen Yan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Medicine, Research & Experimental

CAR therapy: the CD19 paradigm

Michel Sadelain

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Medicine, Research & Experimental

Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade

Elizabeth Buchbinder et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Medicine, Research & Experimental

Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future

Lieping Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biotechnology & Applied Microbiology

Improved stability and efficacy of chitosan/pDNA complexes for gene delivery

Noemi Cifani et al.

BIOTECHNOLOGY LETTERS (2015)

Article Oncology

Cytokines in Cancer Immunotherapy

Sylvia Lee et al.

Cancers (2011)

Article Oncology

Intratumoral delivery of encapsulated IL-12, IL-18 and TNF-α in a model of metastatic breast cancer

Michael S. Sabel et al.

BREAST CANCER RESEARCH AND TREATMENT (2010)

Article Chemistry, Multidisciplinary

Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

Ryo Suzuki et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Article Medicine, General & Internal

Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer

Ignace Vergote et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Immunology

Historical insights into cytokines

Charles A. Dinarello

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Article Chemistry, Multidisciplinary

Synthesis and application of a non-viral gene delivery system for immunogene therapy of cancer

JG Fewell et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Review Pharmacology & Pharmacy

The design and development of pegfilgrastim (PEG-rmetHuG-CSF, neulasta((R)))

G Molineux

CURRENT PHARMACEUTICAL DESIGN (2004)

Article Immunology

Tumor rejection by disturbing tumor stroma cell interactions

S Ibe et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)