Journal
EPIGENETICS & CHROMATIN
Volume 15, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13072-022-00435-w
Keywords
Saccharomyces cerevisiae; Schizosaccharomyces pombe; Heterochromatin structural proteins; SIR complex; Swi6
Categories
Funding
- National Research Foundation of Korea [NRF-2018R1D1A1A02048280, NRF-2019H1A2A1075974, NRF2020R1A6A3A13077356, NRF-2020R1I1A3072234]
- National Research Foundation of Korea [2019H1A2A1075974] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study, although they have different mechanisms for heterochromatin formation and maintenance, they share important common features in the heterochromatin structural proteins.
Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S. cerevisiae does not have known epigenetic silencing markers and instead has Sir proteins to regulate silent chromatin formation. Although S. cerevisiae and S. pombe form and maintain heterochromatin via mechanisms that appear to be fundamentally different, they share important common features in the heterochromatin structural proteins. Heterochromatin loci are localized at the nuclear periphery by binding to perinuclear membrane proteins, thereby producing distinct heterochromatin foci, which sequester heterochromatin structural proteins. In this review, we discuss the nuclear peripheral anchoring of heterochromatin foci and its functional relevance to heterochromatin formation and maintenance.
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