4.4 Review

Osteoporosis therapies and their mechanisms of action (Review)

Journal

EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 22, Issue 6, Pages -

Publisher

SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2021.10815

Keywords

osteoporosis treatment; osteoblast; osteoclast; bone resorption; bone formation; bone remodeling; menopause; fracture

Funding

  1. Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education in Korea [NRF-2021R1I1A3046499, NRF2021R1I1A1A01049248, NRF-2019R1G1A1100099]

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Osteoporosis is a common disease characterized by low bone density and increased risk of fractures, mainly affecting menopausal women. Research into novel therapeutic methods is necessary. Treatment options for osteoporosis vary, including both established and newly developed drugs.
Osteoporosis is a common disease that affects millions of patients worldwide and is most common in menopausal women. The main characteristics of osteoporosis are low bone density and increased risk of fractures due to deterioration of the bone architecture. Osteoporosis is a chronic disease that is difficult to treat; thus, investigations into novel effective therapeutic methods are required. A number of studies have focused on determining the most effective treatment options for this disease. There are several treatment options for osteoporosis that differ depending on the characteristics of the disease, and these include both well-established and newly developed drugs. The present review focuses on the various drugs available for osteoporosis, the associated mechanisms of action and the methods of administration.

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