High myopia and macular vascular density: an optical coherence tomography angiography study

Objective To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method OCTA was performed on 35 eyes with HM with spherical equivalence (SE) > - 6.00D and 35 eyes with NHM with SE <= -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each of the superficial, deep and choriocapillaris layers of the retina. Results In the superficial retinal layer, overall macular VFD was significantly higher in the NHM compared to the HM group (51.27 +/- 3.74 vs. 48.07 +/- 5.69, p < 0.05). There were significant differences between the NHM and HM in parafovea (52.58 +/- 5.78 vs. 49.4 +/- 6.43, p < 0.05), superior-hemi (53.38 +/- 4.03 vs 49.78 +/- 6.84, p < 0.05) and inferior-hemi regions (53.49 +/- 4.61 vs 49.05 +/- 6.41, p < 0.05), but not in the fovea region. Similarly, in the deep retinal layer, overall macular VFD was significantly higher in the NHM group compared to the HM group (58.69 +/- 2.46 vs. 56.90 +/- 4.08, p < 0.05). There was significant differences between the HM and NHM in superior-hemi region (61.97 +/- 2.68 vs. 60.08 +/- 3.98, p < 0.05), but not in the fovea, parafovea, and inferior-hemi region. In the choriocapillaris, there was no difference in the overall macular VFD, nor any of the individual sectors between the HM and the NHM groups. Conclusion VFD in the superficial and deep retinal layers of the macula are significantly increased in the NHM compared to HM eyes. This is not the case in the choroidal capillary layers of the retina.

Automated summary

The study compared macular vascular density between patients with high-myopia and non-high myopia using OCTA. Results showed that vascular densities in the superficial and deep retinal layers of the macula were significantly higher in non-high myopia patients compared to high-myopia patients, while no differences were observed in the choriocapillaris layer.