4.7 Article

Initiation of hepatic stellate cell activation extends into chronic liver disease

Related references

Note: Only part of the references are listed.
Review Cell Biology

The Power of Plasticity?Metabolic Regulation of Hepatic Stellate Cells

Parth Trivedi et al.

Summary: Hepatic stellate cells play a crucial role in regulating physiological and pathological responses in the liver, particularly in chronic liver injury. They drive hepatic fibrosis and are involved in inflammation and cancer by adapting metabolic pathways to meet increased energy demands.

CELL METABOLISM (2021)

Article Gastroenterology & Hepatology

Heterogeneity of HSCs in a Mouse Model of NASH

Sara Brin Rosenthal et al.

Summary: This study utilized single-cell RNA sequencing to characterize the phenotypic changes of hepatic stellate cells (HSCs) in a NASH model, revealing unexpected heterogeneity of HSC phenotypes under normal and injured states. The NASH livers showed four distinct HSC clusters, including one representing the classic fibrogenic myofibroblast, while livers with NASH regression had one cluster of inactivated HSCs similar to quiescent HSCs.

HEPATOLOGY (2021)

Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Biochemical Research Methods

Orbit Image Analysis: An open-source whole slide image analysis tool

Manuel Stritt et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemistry & Molecular Biology

Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets

Frederic Pont et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

P. Ramachandran et al.

NATURE (2019)

Article Gastroenterology & Hepatology

Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies

Laura Pimpin et al.

JOURNAL OF HEPATOLOGY (2018)

Article Multidisciplinary Sciences

RAP2 mediates mechanoresponses of the Hippo pathway

Zhipeng Meng et al.

NATURE (2018)

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Medicine, General & Internal

Use of Liver Imaging and Biopsy in Clinical Practice

Elliot B. Tapper et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Gastroenterology & Hepatology

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Inge Mannaerts et al.

JOURNAL OF HEPATOLOGY (2015)

Article Biotechnology & Applied Microbiology

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Mihaela Pertea et al.

NATURE BIOTECHNOLOGY (2015)

Article Cell Biology

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Francesca Zanconato et al.

NATURE CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Gastroenterology & Hepatology

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Juliane S. Troeger et al.

GASTROENTEROLOGY (2012)

Article Biochemical Research Methods

A framework for oligonucleotide microarray preprocessing

Benilton S. Carvalho et al.

BIOINFORMATICS (2010)

Article Gastroenterology & Hepatology

Acute Liver Failure Is Associated With Elevated Liver Stiffness and Hepatic Stellate Cell Activation

Alexander Dechene et al.

HEPATOLOGY (2010)

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

affy -: analysis of Affymetrix GeneChip data at the probe level

L Gautier et al.

BIOINFORMATICS (2004)

Review Biochemistry & Molecular Biology

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

SL Friedman

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)