Simultaneous or staged resection of synchronous colorectal cancer liver metastases: a 13-year institutional follow-up

Background: This study compared postoperative outcomes and survival rates of patients who un-derwent simultaneous or staged resection for synchronous colorectal cancer liver metastases. Methods: Between 2005 and 2018, 126 patients were registered prospectively at a university hospital in Sweden, 63 patients who underwent simultaneous resection were matched against 63 patients who underwent staged resection.Results: The length of hospital stay was shorter for the simultaneous resection group, at 11 vs 16 days, p = <0.001. Fewer patients experienced recurrence in the simultaneous resection group 39 vs 50 pa-tients, p = 0.012. There were no significant differences in disease-free survival and overall survival be-tween the groups. Age (hazard ratio [HR] 1.72; 95% CI 1.01-2.94; p = 0.049) and Clavien-Dindo score (HR 2.22; 95% CI 1.06-4.67; p = 0.035) had impact on survival. Conclusion: Colorectal cancer with synchronous liver metastases can be resected simultaneously, and enables a shorter treatment time without jeopardizing oncological outcomes.

Automated summary

This study compared postoperative outcomes and survival rates of patients who underwent simultaneous or staged resection for synchronous colorectal cancer liver metastases. The simultaneous resection group had shorter hospital stay and lower recurrence rate compared to the staged resection group. There were no significant differences in disease-free survival and overall survival between the two groups. Age and Clavien-Dindo score had an impact on survival.