Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 86, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2021.104674
Keywords
Food derived peptides; Functional food; Nutrition; Anti-diabetic; Natural resources
Categories
Funding
- National Natural Science Foundation of Ningxia Province [2021AAC02019]
- Youth talent cultivation project of North Minzu University [2021KYQD27]
- Major Projects of Science and Technology in Anhui Province [201903a06020021, 202004a06020042, 202004a06020052, 201904a06020008]
- National Natural Science Foundation of China [31850410476]
- Fundamental Research Funds for the Central Universities [JZ2019HGTB0061]
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Food-derived peptides and protein hydrolysates have been reported to provide additional health benefits such as lowering blood pressure, antioxidant properties, and antimicrobial attributes, which can be used in the control of hypertension, management of type 2 diabetes, and reduction of oxidative stress. Efficacy assessment and sufficient absorption are key factors in ensuring the systemic effects of these bioactive peptides.
In recent years, burgeoning reports have emphasized that food-derived peptides and protein hydrolysates can confer additional health benefits beyond nutritional role. The biologically active peptides are regarded as nutraceuticals and functional food ingredients displaying antihypertensive, antioxidant, mineral binding, maintenance of intestinal barrier function, and antimicrobial attributes. The food-derived bioactive peptides serve as an alternative to pharmacological treatments in the control of hypertension, the management of type 2 diabetes (T2D), and oxidative stress. This review integrates the existing information on plant and animal proteins with a particular focus on anti-diabetic inhibitory peptides. Besides, their modes of inhibition and structure-activity relationship of peptide inhibitors are also discussed. To elicit systemic effects, efficacy assessment and sufficient absorption are the key factors which have been proved by in vitro and in vivo studies, particularly if health-related claims are to be made.
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