Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 88, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2021.104910
Keywords
Tetrastigma hemsleyanum; Sarcoidosis; Metabolomics; Inflammatory immune response; Network pharmacology
Categories
Funding
- Major Science and Technology Projects of Breeding New Varieties of Agriculture in Zhejiang Province [2021C02074]
- Zhejiang Province Science and Technology Plan of Traditional Chinese Medicine [2019ZQ042]
- General Scientific Research Project of Zhejiang Provincial Department of Education [Y201840500]
- Ningbo City Science and Technology Innovation 2025 Major Research Project [2019B10008]
- Fund of Zhejiang pharmaceutical college [XY2020004]
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This study confirmed the protective effects of Tetrastigma hemsleyanum on sarcoidosis and revealed its mechanism of action. T. hemsleyanum treats sarcoidosis by suppressing inflammation, maintaining immune balance, and regulating metabolism.
This study investigated the protective effects and mechanism of Tetrastigma hemsleyanum (T. hemsleyanum) in sarcoidosis mice. Through the integrated analysis of network pharmacology, molecular docking and HPLC, oleanolic acid, procyanidin B1 and beta-sitosterol were considered to be the major components of T. hemsleyanum against sarcoidosis. T. hemsleyanum remarkably attenuated the increase of IL-6 and IL-17A, the percentage of Th17 cells by 33. 85%-63.00% and the expression of ROR gamma t in a dose-dependent manner (P < 0.01). Simultaneously, T. hemsleyanum obviously elevated the levels of IL-35 and TGF-beta, accompanied by the increasing expression of Foxp3 in a dose-dependent manner and the enhancement of Treg cells proportion (P < 0.01). Furthermore, T. hemsleyanum could regulate the levels of 22 endogenous metabolites involved in linoleic acid, arachidonic acid, and glycerophospholipid metabolism. Comprehensively, the therapeutic effect of T. hemsleyanum on sarcoidosis was achieved by suppressing the inflammatory response, maintaining Th17/Treg immune homeostasis and regulating abnormal glycerolipid metabolism.
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