Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 86, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2021.104722
Keywords
Air pollution; Immune cells; Lung inflammation; Proinflammatory cytokines; Propolis
Categories
Funding
- New Zealand Ministry of Business, Innovation and Employment High-Value Nutrition National Science Challenge grant [UoAX1313, HVNCA003]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [UOAX1313] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
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The study showed that dietary propolis consumption can reduce urban dust-induced lung proinflammatory cytokine production in a mouse model, but does not affect immune cell infiltration into the lung or lung function outcomes.
Air pollution is estimated to cause 7 million annual deaths globally. Our aim was to determine if dietary propolis consumption could prevent the immune and functional damage in a mouse model of acute urban dust exposure. Female C57BL/6J mice were challenged three times with intranasal urban dust over seven days which significantly increased proinflammatory cytokines and immune cells in the lung 24 h post final challenge. Dietary New Zealand propolis (2%) with gamma cyclodextrin supplementation reduced urban dust-induced lung TNF alpha, IL-4, and IL-6 cytokine production; but did not alter immune cell infiltration into the lung, or lung function outcomes. This suggests that daily consumption of 8% propolis with gamma cyclodextrin supplemented food was sufficient to reduce urban dust pollution-induced proinflammatory cytokine production but was not sufficient to prevent immune cell recruitment into the lung or lung function decline in a murine model of lung inflammation.
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