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Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples

Journal

BIOANALYSIS
Volume 13, Issue 20, Pages 1569-1584

Publisher

Newlands Press Ltd
DOI: 10.4155/bio-2021-0180

Keywords

analytical techniques; hippuric acid; methyl hippuric acid; toluene; urine; xylene

Funding

  1. Hangzhou Foundation for Development of Science and Technology [20181228Y28]
  2. Hangzhou medical and health science and technology project [0020190983, A20210491]

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Analytical techniques for monitoring hippuric acid and methylhippuric acid in human urine matrices from 2016 to 2021 were presented in this study, using high performance liquid chromatography coupled with UV detection. This provides valuable information on toluene and xylene exposure conditions.
Quantification of hippuric acid and methylhippuric acid in human urine matrices provides information on the toluene and xylene exposure conditions. High performance liquid chromatography coupled with UV detection is the preferable technique for hippuric acid and methylhippuric acid detection in human urine. This study was conducted to present analytical techniques developed for monitoring of hippuric acid and methylhippuric acid in human urine matrices during 2016-2021.

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