Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.815280
Keywords
SPIO; SMF; neural stem cells; proliferation; regulation
Categories
Funding
- Major State Basic Research Development Program of China (973 Program) [2017YFA0104303]
- National Natural Science Foundation of China [81970883]
- Hefei University Scientific Research and Development Fund [20ZR08ZDA]
Ask authors/readers for more resources
SPIOs have good biocompatibility and adhesion, and can promote NSC proliferation in the presence of static magnetic field, which is of significant importance for tissue engineering and regenerative medicine.
Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 mu g/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 +/- 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available