Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.761416
Keywords
photoreceptor; rod; cone; phototransduction; olfaction; olfactory sensory neuron; vision; signal transduction
Categories
Funding
- National Institutes of Health [R21DC018358, R01DC016647, EY027387, EY025696, EY02687]
- Research to Prevent Blindness
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The past decades have seen significant progress in understanding the function of photoreceptors and olfactory sensory neurons. This progress has been driven by the combination of physiological experimental tools and genetic manipulations, which have allowed researchers to identify molecular players in sensory neuron transduction cascades, explore how properties impact stimulus detection and disease effects on vision and smell.
The past decades have seen tremendous progress in our understanding of the function of photoreceptors and olfactory sensory neurons, uncovering the mechanisms that determine their properties and, ultimately, our ability to see and smell. This progress has been driven to a large degree by the powerful combination of physiological experimental tools and genetic manipulations, which has enabled us to identify the main molecular players in the transduction cascades of these sensory neurons, how their properties affect the detection and discrimination of stimuli, and how diseases affect our senses of vision and smell. This review summarizes some of the common and unique features of photoreceptors and olfactory sensory neurons that make these cells so exciting to study.
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