4.6 Article

Dietary Choline Protects Against Cognitive Decline After Surgery in Mice

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Summary: The APOE gene's E4 allele is a genetic risk factor for cardiovascular diseases and Alzheimer's disease, but its mechanism of action is poorly understood. A study found that APOE4 disrupted cellular lipidomes, leading to increased unsaturation of fatty acids and intracellular lipid droplet accumulation. Supplementation with choline restored the cellular lipidome in APOE4-expressing cells, suggesting that manipulating lipid metabolism could be a therapeutic approach for individuals with the APOE4 allele.

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