4.1 Review

Applying implementation science to improve care for familial hypercholesterolemia

Journal

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MED.0000000000000692

Keywords

cascade screening; familial hypercholesterolemia; identification; implementation science

Funding

  1. National Heart, Lung, and Blood Institute [K12HL137942]
  2. National Cancer Institute [P50CA244431]
  3. National Institute of Diabetes and Digestive and Kidney Diseases [P30DK092950, R25DK123008]
  4. Centers for Disease Control and Prevention [U48DP006395]

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This review discusses implementation strategies for improving care of individuals with familial hypercholesteremia (FH) and compares them with expert-recommended change strategies. The study finds that only a few studies have used implementation science theories or frameworks, and only a couple of studies explicitly address health disparities or equity.
Purpose of review Improving care of individuals with familial hypercholesteremia (FH) is reliant on the synthesis of evidence-based guidelines and their subsequent implementation into clinical care. This review describes implementation strategies, defined as methods to improve translation of evidence into FH care, that have been mapped to strategies from the Expert Recommendations for Implementing Change (ERIC) compilation. Recent findings A search using the term 'familial hypercholesterolemia' returned 1350 articles from November 2018 to July 2021. Among these, there were 153 articles related to improving FH care; 1156 were excluded and the remaining 37 were mapped to the ERIC compilation of strategies: assess for readiness and identify barriers and facilitators [9], develop and organize quality monitoring systems [14], create new clinical teams [2], facilitate relay of clinical data to providers [4], and involve patients and family members [8]. There were only 8 of 37 studies that utilized an implementation science theory, model, or framework and two that explicitly addressed health disparities or equity. Summary The mapping of the studies to implementation strategies from the ERIC compilation provides a framework for organizing current strategies to improve FH care. This study identifies potential areas for the development of implementation strategies to target unaddressed aspects of FH care.

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