Journal
CHEMICAL SCIENCE
Volume 13, Issue 8, Pages 2378-2384Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc00113f
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [444632635]
- Studienstiftung des deutschen Volkes
- TUM foundation
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This study presents a highly enantioselective crossed [2+2] photocycloaddition reaction that can produce intriguing bridged skeletons.
In intramolecular [2+2] photocycloaddition reactions, the two tethered olefins can approach each other in a straight or in a crossed fashion. Despite the fact that the latter reaction mode leads to intriguing, otherwise inaccessible bridged skeletons, there has so far not been any enantioselective variants thereof. This study concerned the crossed [2+2]-photocycloaddition of 2-(alkenyloxy)cyclohex-2-enones to bridged cyclobutanes. It was found that the reaction could be performed with high enantioselectivity (80-94% ee) under visible light conditions when employing a chiral rhodium Lewis acid as a catalyst (2 mol%).
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