Journal
CHEMICAL SCIENCE
Volume 13, Issue 10, Pages 3002-3008Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc07248j
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Funding
- National Key R&D Program of China [2021YFA1500100]
- National Natural Science Foundation of China [22031008]
- Science Foundation of Wuhan [2020010601012192]
- Institution Fund Projects [IFPIP: 438135-1442]
- Ministry of Education
- King Abdulaziz University, DSR, Jeddah, Saudi Arabia
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In this study, a facile and novel electrochemical method was developed for the synthesis of tertiary phosphines with excellent yields. The protocol showed good reaction selectivity and scalability.
Tertiary phosphines(iii) find widespread use in many aspects of synthetic organic chemistry. Herein, we developed a facile and novel electrochemical oxidative N-H/P-H cross-coupling method, leading to a series of expected tertiary phosphines(iii) under mild conditions with excellent yields. It is worth noting that this electrochemical protocol features very good reaction selectivity, where only a 1 : 1 ratio of amine and phosphine was required in the reaction. Moreover, this electrochemical protocol proved to be practical and scalable. Mechanistic insights suggested that the P radical was involved in this reaction.
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