Journal
JOURNAL OF TOXICOLOGIC PATHOLOGY
Volume 35, Issue 1, Pages 113-116Publisher
JAPANESE SOC TOXICOLOGIC PATHOLOGY
DOI: 10.1293/tox.2021-0054
Keywords
lipomatosis; adipocytes; axillary lymph node; cynomolgus monkey; spontaneous lesion
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This report describes the first case of lymph node lipomatosis in a young adult cynomolgus monkey with bilateral axillary lymph nodes. Macroscopic and histopathological examination revealed the replacement of lymphatic parenchyma by adipose tissue without any malignant findings.
Lipomatosis of lymph nodes is defined as the replacement of the lymphatic parenchyma by adipose tissue which grows in the node from the hilus toward the cortical zone. In humans, it is considered as part of the normal aging process and is common in obese patients, but there are no reports in non-human primates. In this report, we describe the first case of lymph node lipomatosis in the bilateral axillary lymph nodes of a young adult cynomolgus monkey. Macroscopically, there were no apparent abnormalities in the axillary lymph nodes on either side, and their volumes were unchanged. At the cut surface, pale yellow fat-like tissue was observed in the medullary area. IIistopathologically, well differentiated adipocytes replaced a large part of the lymphatic parenchyma in the area from the hilus to the medulla without any malignant findings. Based on these findings, the patient was diagnosed with lipomatosis of the lymph nodes.
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