Journal
VIRUSES-BASEL
Volume 13, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/v13102068
Keywords
respiratory viruses; metabolism; host targeted antivirals
Categories
Funding
- German Research Foundation (DFG) [SFB1009 B02, SFB1009 B13, CRU342 P6, Lu477-23]
- Juergen Manchot Stiftung, Duesseldorf, Germany
- Open Access Publication Fund of the University of Muenster
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Respiratory viruses rely on host cells for replication and actively induce certain cellular functions for their own benefit, including modifying metabolic pathways such as glycolysis, fatty acid synthesis, and the tricarboxylic acid cycle. Studying the modifications of metabolic pathways mediated by these viruses can help identify potential targets and compounds for therapeutic approaches.
Respiratory viruses are known to be the most frequent causative mediators of lung infections in humans, bearing significant impact on the host cell signaling machinery due to their host-dependency for efficient replication. Certain cellular functions are actively induced by respiratory viruses for their own benefit. This includes metabolic pathways such as glycolysis, fatty acid synthesis (FAS) and the tricarboxylic acid (TCA) cycle, among others, which are modified during viral infections. Here, we summarize the current knowledge of metabolic pathway modifications mediated by the acute respiratory viruses respiratory syncytial virus (RSV), rhinovirus (RV), influenza virus (IV), parainfluenza virus (PIV), coronavirus (CoV) and adenovirus (AdV), and highlight potential targets and compounds for therapeutic approaches.
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