SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives

SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed.

Automated summary

SARS-CoV-2, the causative agent of the COVID-19 pandemic, has a large RNA genome that generates a tiered ensemble of subgenomic RNAs (sgRNAs). Comprehensive understanding of these RNA products is crucial for studying SARS-CoV-2 pathogenesis. Recent progress in identifying, characterizing, and utilizing SARS-CoV-2 sgRNAs as viral replication markers is discussed along with the significance of these findings and potential future research areas.