4.6 Review

Inositol Phosphates and Retroviral Assembly: A Cellular Perspective

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Analytical Methods for Determination of Phytic Acid and Other Inositol Phosphates: A Review

Gregor Marolt et al.

Summary: This paper critically reviews the development of analytical principles and methods for analyzing phytic acid and other inositol phosphates in biological samples, highlighting the challenges and importance of such analysis. It outlines the evolution of techniques from classical methods to the latest bio- and nano-sensors.

MOLECULES (2021)

Article Virology

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses

Alzbeta Dostalkova et al.

Summary: IP6 was found to stimulate the assembly of immature particles of lentiviruses, with cryo-electron tomography showing a similar binding site in HIV-1 and EIAV. While the effect may be unique to lentiviruses, it is possible that other retroviral species also utilize small polyanions for particle assembly.

VIRUSES-BASEL (2021)

Article Microbiology

Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells

Gregory A. Sowd et al.

Summary: Our study demonstrates that inositol phosphates, IP5 and IP6, play crucial roles in HIV-1 assembly and maturation. Depletion of IP5 and IP6 in T cells resulted in impaired viral particle assembly and reduced infectivity of produced virions. These findings suggest that targeting HIV-1 inositol phosphate binding pockets may inhibit distinct aspects of HIV-1 replication.

PLOS PATHOGENS (2021)

Review Virology

The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle

Bo Meng et al.

Summary: Viruses are obligate parasites that rely on host cellular factors for replication and spread, often hijacking host machinery such as the ESCRT system. Research on ESCRT and viruses has advanced our understanding of various cellular functions, with a special focus on the interplay between the ESCRT pathway and enveloped viruses like retroviruses.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

A stable immature lattice packages IP6 for HIV capsid maturation

Donna L. Mallery et al.

Summary: HIV maintains immature lattice stability to ensure IP6 packaging while allowing maturation. Mutant viruses with reduced IP6 recruitment show increased infectivity upon treatment with MIs or second-site compensatory mutations.

SCIENCE ADVANCES (2021)

Article Virology

Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency

Daniel Poston et al.

Summary: The assembly and maturation of HIV-1 virions rely on cellular polyanion IP6 binding to primary amines on Gag or CA hexamers. Mutations affecting IP6 binding can lead to assembly deficits, but compensatory mutations like T371I can restore replication competence. Moreover, the maturation inhibitor Bevirimat (BVM) can also rescue assembly and replication of IP6-binding deficient mutants, offering insights into HIV-1 virion assembly events.

RETROVIROLOGY (2021)

Article Multidisciplinary Sciences

Maturation of the matrix and viral membrane of HIV-1

Kun Qu et al.

Summary: The study found that MA rearranges between different hexameric lattices in the maturation process of HIV-1, binding with lipid extending out of the membrane in mature HIV-1. The data suggest that proteolytic maturation of HIV-1 assembles the viral capsid and repurposes the membrane-bound MA lattice for cell entry or post-entry function, resulting in the removal of up to 2500 lipids from the viral membrane.

SCIENCE (2021)

Review Virology

When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

Kevin M. Rose

Summary: Proper assembly and dissemination of progeny virions is crucial for virus replication, with viruses evolving various strategies to exploit cellular mechanisms for successful infection. Different viruses, such as retroviruses and herpesviruses, utilize host ESCRT complexes in distinct ways to ensure viral particle formation. Despite occurring in separate subcellular compartments and at different steps, the role of ESCRTs in viral lifecycles appears to be conserved.

VIRUSES-BASEL (2021)

Review Virology

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly

Martin Obr et al.

Summary: IP6, a small cellular molecule, facilitates the assembly of HIV-1 and other retroviruses into virus-like particles in vitro, enhancing core stability during reverse transcription process.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer

Martin Obr et al.

Summary: IP6 serves as a more potent assembly cofactor for RSV than for HIV-1, and its removal in cells significantly reduces RSV infectivity. Visualized structures of mature capsids show IP6-like density in the CA hexamer, coordinated by lysines and arginines, with phosphate and IP6 affecting CA assembly differently. The flexibility of CA hexamers and rigidity of pentamers determine the variable shape of CA polyhedrons in mature RSV particles.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein

Halilibrahim Ciftci et al.

Summary: The oligomerization of Pr55(Gag) is a critical step in the late stage of the HIV life cycle, with the binding of IP6 at the MA domain playing a key role. The crystal structures of the MA domain in complex with IP6 molecules provide insights into the binding mode, while analysis of key residues and interactions with PIP2 reveal a multilayered assembly process involving coordination between IP6 and PIP2 for membrane localization of virion particles. Additionally, a new model is proposed based on the structures, suggesting that IP6 coordinates the oligomerization of MA and CA domains during assembly and budding.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease

Boah Lee et al.

Summary: IPMK is a promiscuous enzyme with broad substrate specificity, phosphorylating multiple inositol phosphates and phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK can control signaling events via direct protein-protein interactions. It plays pleiotropic roles in physiological and pathological conditions.

MOLECULES AND CELLS (2021)

Article Virology

Biochemical Reconstitution of HIV-1 Assembly and Maturation

Iga Kucharska et al.

JOURNAL OF VIROLOGY (2020)

Review Biochemistry & Molecular Biology

a Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

Seulgi Lee et al.

MOLECULES (2020)

Article Multidisciplinary Sciences

Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism

Isabella M. Acquistapace et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

Devin E. Christensen et al.

SCIENCE (2020)

Review Virology

HIV-1 Maturation: Lessons Learned from Inhibitors

Alex B. Kleinpeter et al.

VIRUSES-BASEL (2020)

Article Biochemistry & Molecular Biology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

Chaoyi Xu et al.

PLOS BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Signalling Properties of Inositol Polyphosphates

Tania Maffucci et al.

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Role of Inositols and Inositol Phosphates in Energy Metabolism

Saimai Chatree et al.

MOLECULES (2020)

Article Biochemistry & Molecular Biology

Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature

Halil I. Ciftci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase

Wooseob Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Virology

Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions

Ayna Alfadhli et al.

JOURNAL OF VIROLOGY (2019)

Article Biochemistry & Molecular Biology

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation

Carmen A. Buttler et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Inositol phosphates are assembly co-factors for HIV-1

Robert A. Dick et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

Benjamin J. Schmiedel et al.

Article Multidisciplinary Sciences

Structure and architecture of immature and mature murine leukemia virus capsids

Kun Qu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Virology

Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly

Sanela Rankovic et al.

JOURNAL OF VIROLOGY (2017)

Review Biochemistry & Molecular Biology

The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub

Eunha Kim et al.

MOLECULES AND CELLS (2017)

Article Biochemistry & Molecular Biology

Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase

Elsa Franco-Echevarria et al.

PROTEIN JOURNAL (2017)

Article Multidisciplinary Sciences

A subcellular map of the human proteome

Peter J. Thul et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

A pathology atlas of the human cancer transcriptome

Mathias Uhlen et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation

Philip R. Tedbury et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation

Florian K. M. Schur et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

The structure and flexibility of conical HIV-1 capsids determined within intact virions

Simone Mattei et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Cellular Internalisation of an Inositol Phosphate Visualised by Using Fluorescent InsP5

Andrew M. Riley et al.

CHEMBIOCHEM (2014)

Article Multidisciplinary Sciences

Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly

Tanmay A. M. Bharat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Microbiology

The roles of lipids and nucleic acids in HIV-1 assembly

Ayna Alfadhli et al.

FRONTIERS IN MICROBIOLOGY (2014)

Article Virology

In Vitro Assembly of Retroviruses

Di L. Bush et al.

ANNUAL REVIEW OF VIROLOGY, VOL 1 (2014)

Review Microbiology

Virus Budding and the ESCRT Pathway

Joerg Votteler et al.

CELL HOST & MICROBE (2013)

Article Biochemistry & Molecular Biology

Conformational Stability of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Dictates Its Substrate Selectivity

Varin Gosein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Inositol phosphates compete with nucleic acids for binding to bovine leukemia virus matrix protein: Implications for deltaretroviral assembly

Dominic F. Qualley et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

Structural Studies and Protein Engineering of Inositol Phosphate Multikinase

Stuart Endo-Streeter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

Tanmay A. M. Bharat et al.

NATURE (2012)

Article Multidisciplinary Sciences

Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy

Jakub Chojnacki et al.

SCIENCE (2012)

Article Microbiology

Clathrin Facilitates the Morphogenesis of Retrovirus Particles

Fengwen Zhang et al.

PLOS PATHOGENS (2011)

Article Microbiology

Structural Analysis of HIV-1 Maturation Using Cryo-Electron Tomography

Alex de Marco et al.

PLOS PATHOGENS (2010)

Article Multidisciplinary Sciences

Structure and assembly of immature HIV

J. A. G. Briggs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Do mammals make all their own inosital hexakisphasphate?

Andrew J. Letcher et al.

BIOCHEMICAL JOURNAL (2008)

Article Biochemistry & Molecular Biology

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase

Maria A. Brehm et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells

Elizabeth R. Wright et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Interactions between HIV-1 Gag molecules in solution: An inositol phosphate-mediated switch

Siddhartha A. K. Datta et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly

Jamil S. Saad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemical Research Methods

Extraction and analysis of soluble inositol polyphosphates from yeast

Cristina Azevedo et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Entropic switch regulates myristate exposure in the HIV-1 matrix protein

C Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The stoichiometry of Gag protein in HIV-1

JAG Briggs et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Modulation of HIV-like particle assembly in vitro by inositol phosphates

S Campbell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Cell Biology

Back in the water: The return of the inositol phosphates

RF Irvine et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

Review Cell Biology

Assessing the omnipotence of inositol hexakisphosphate

SB Shears

CELLULAR SIGNALLING (2001)

Article Biochemistry & Molecular Biology

Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo

HB Chi et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Biochemistry & Molecular Biology

A conformational switch controlling HIV-1 morphogenesis

I Gross et al.

EMBO JOURNAL (2000)