Journal
VIRUSES-BASEL
Volume 14, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v14010079
Keywords
SARS-CoV-2; COVID-19; Omicron; variants; T cell epitopes; mutations; insertions; deletions; peptide-HLA binding
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The study assessed the impact of Omicron mutations on known T cell epitopes and found that T cell responses to this new variant remain robust.
Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple mutations in the spike protein that were not observed in previous VOCs. Initial studies suggest Omicron to substantially reduce the neutralizing capability of antibodies induced from vaccines and previous infection. However, its effect on T cell responses remains to be determined. Here, we assess the effect of Omicron mutations on known T cell epitopes and report data suggesting T cell responses to remain broadly robust against this new variant.
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