4.6 Article

Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells

Related references

Note: Only part of the references are listed.
Article Virology

C1QBP inhibits proliferation of porcine circovirus type 2 by restricting nuclear import of the capsid protein

Xin Ma et al.

Summary: This study demonstrated that C1QBP interacts with the Cap NLS region, resulting in changes in the intracellular localisation of the Cap protein. Overexpression of C1QBP inhibits the proliferation of PCV2, possibly related to the function of C1QBP in controlling nuclear transport of Cap.

ARCHIVES OF VIROLOGY (2021)

Review Cell Biology

Emerging Roles of TRIM8 in Health and Disease

Flaviana Marzano et al.

Summary: TRIM8, a member of the TRIM protein family, plays crucial roles in immune response, carcinogenesis, and cell survival, among other biological processes. Apart from its ubiquitination functions, TRIM8 can act as either an oncogene or a tumor suppressor gene, selectively regulating three pivotal cellular signaling pathways.

CELLS (2021)

Article Virology

TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein

Hua Wang et al.

Summary: The study reveals that TRIM21 inhibits the proliferation of PEDV by degrading the N protein, with its overexpression suppressing viral replication and knockdown leading to increased viral titers and N protein levels. TRIM21 interacts with and colocalizes with the N protein, and its antiviral effect is dependent on its ubiquitin ligase activity, which leads to the polyubiquitination and degradation of the N protein in a proteasome-dependent manner.

ARCHIVES OF VIROLOGY (2021)

Review Immunology

The Roles of TRIMs in Antiviral Innate Immune Signaling

Zhou Shen et al.

Summary: The TRIM protein family, the largest subfamily of the RING-type E3 ubiquitin ligase family in humans, is involved in regulating various cellular functions. Studies have shown that many TRIM proteins play antiviral roles by affecting viral replication and the signaling pathways of antiviral innate immune responses.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Microbiology

NAP1L4 inhibits porcine circovirus type 2 replication via IFN-β signaling pathway

Shengnan Wang et al.

VETERINARY MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome

Yinjing Song et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Virology

The interplay between viruses and TRIM family proteins

Ramisha Khan et al.

REVIEWS IN MEDICAL VIROLOGY (2019)

Article Virology

TRIM Proteins and Their Roles in Antiviral Host Defenses

Michiel van Gent et al.

ANNUAL REVIEW OF VIROLOGY, VOL 5 (2018)

Review Biochemistry & Molecular Biology

TRIM proteins and diseases

Masashi Watanabe et al.

JOURNAL OF BIOCHEMISTRY (2017)

Review Rheumatology

A review of the role and clinical utility of anti-Ro52/TRIM21 in systemic autoimmunity

Adrian Y. S. Lee

RHEUMATOLOGY INTERNATIONAL (2017)

Review Biochemistry & Molecular Biology

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

Shigetsugu Hatakeyama

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Review Immunology

The TRIMendous Role of TRIMs in Virus-Host Interactions

Sarah van Tol et al.

VACCINES (2017)

Article Pharmacology & Pharmacy

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism

Wenchun Fan et al.

ANTIVIRAL RESEARCH (2016)

Review Genetics & Heredity

Interactions of porcine circovirus 2 with its hosts

Linzhu Ren et al.

VIRUS GENES (2016)

Article Pharmacology & Pharmacy

Effect of atovastatin treatment on porcine circovirus 2 infection in BALB/c mice

Xin Yang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2015)

Article Multidisciplinary Sciences

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Manuel Stemmer et al.

PLOS ONE (2015)

Article Genetics & Heredity

Genome-wide association studies for hematological traits in Chinese Sutai pigs

Feng Zhang et al.

BMC GENETICS (2014)

Article Biochemistry & Molecular Biology

Expression, purification and antibody preparation using different constructs of PCV2 capsid protein

Fuwang Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2014)

Article Biotechnology & Applied Microbiology

HMG-CoA reductase is negatively associated with PCV2 infection and PCV2-induced apoptotic cell death

Xin Yang et al.

JOURNAL OF GENERAL VIROLOGY (2014)

Article Virology

Complete Genome Sequence of Porcine Circovirus 2b Strain CC1

Xin Yang et al.

JOURNAL OF VIROLOGY (2012)

Article Veterinary Sciences

Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs

Alan R. Doster et al.

JOURNAL OF VETERINARY SCIENCE (2010)

Article Biochemistry & Molecular Biology

Enhancement of porcine circovirus 2 replication in porcine cell lines by IFN-γ before and after treatment and by IFN-α after treatment

P Meerts et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2005)

Article Immunology

SS-A/Ro52, an autoantigen involved in CD28-Mediated IL-2 production

T Ishii et al.

JOURNAL OF IMMUNOLOGY (2003)