Journal
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
Volume 648, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/zaac.202100343
Keywords
Metal-organic frameworks; Chemodynamic therapy; Chemotherapy; Drug release
Categories
Funding
- National Natural Science Foundation of China [51802283]
- Zhejiang Provincial Natural Science Foundation of China [LY20E020003]
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A metal-organic framework ZJU-136-Ce with ideal water stability was synthesized and used to load Mn2+ and DOX for tumor chemo/chemodynamic therapy, showing significant inhibition effects on Hela cell growth. It has potential application prospects in multimodal cancer therapy.
A metal-organic framework ZJU-136-Ce with ideal water stability was synthesized. It was adopted to load Mn2+ and DOX for chemo/chemodynamic therapy of tumor, the loading capacity of Mn2+ and DOX was 0.87 wt % and 10.19 wt % in ZJU-136-Ce, respectively. DOX&Mn@ZJU-136-Ce exhibited significant effects of inhibition of Hela cell growth, which confirmed it had a potential application prospect in the multimodal cancer therapy.
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