Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 40, Issue -, Pages 50-56Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2016.07.005
Keywords
Tuna eyeball oil; Anti-inflammation; Nuclear factor kappa B; Ear edema; Mitogen-activated protein kinases
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Funding
- Fishery Commercialization Technology Development Program through KIMST (Korea Institute of Marine Science & Technology promotion) - Ministry of Oceans and Fisheries (MOF) [2013300893]
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The effect of tuna eyeball oil (TEO) on lipopolysaccharide (LPS)-induced inflammation in macrophage cells was investigated. TEO had no cytotoxicity in cell viability as compared to the control in LPS induced RAW 264.7 cells. TEO reduced the levels of NO and pro-inflammatory cytoldnes by up to 50% in a dose-dependent manner. The expression of NF-kappa B and MAPKs as well as iNOS and COX-2 proteins was reduced by TEO, which suggests that its anti-inflammatory activity is related to the suppression of the NF-kappa B and MAPK signaling pathways. The rate of formation of ear edema was reduced compared to that in the control at the highest dose tested. In an acute toxicity test, no mice were killed by TEO doses of up to 5000 mg/kg body weight during the two week observation period. These results suggested that TEO may have a significant effect on inflammatory factors and be a potential anti-inflammatory therapeutic. (C) 2016 Elsevier B.V. All rights reserved.
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