4.7 Article

gga-miR-200b-3p promotes avian leukosis virus subgroup J replication via targeting dual-specificity phosphatase 1

Journal

VETERINARY MICROBIOLOGY
Volume 264, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.vetmic.2021.109278

Keywords

gga-miR-200b-3p; ALV-J; DUSP1

Funding

  1. National Natural Science Foundation of China [31802206, 32072842]
  2. Natural Science Foundation of Guangdong Province [2019A1515012006, 2021A1515011147]
  3. Natural Science Foundation of Guangzhou [202102020942]

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In this study, it was found that gga-miR-200b-3p acts as a positive host factor enhancing ALV-J replication by targeting host protein DUSP1. This highlights the crucial role of gga-miR-200b-3p in the replication of ALV-J.
MicroRNAs (miRNAs) involved host-virus interaction, affecting the replication or pathogenesis of several viruses. Although avian leukosis virus subgroup J (ALV-J) has been one of the most studied avian viruses, the effects of various host miRNAs on ALV-J infection and its underlying molecular mechanisms are still unclear. Here, we reported that gga-miR-200b-3p acts as a positive host factor enhancing ALV-J replication. We found that ggamiR-200b-3p was increased in response to ALV-J infection in host cells, and that gga-miR-200b-3p effectively enhanced ALV-J replication via targeting host protein dual-specificity phosphatase 1 (DUSP1). Collectively, these findings highlight a crucial role of gga-miR-200b-3p in ALV-J replication.

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