miR-10b promotes aortic aneurysm formation and aortic rupture in angiotensin II-induced ApoE-deficient mice

Article Oncology

MicroRNA-10b modulates cisplatin tolerance by targeting p53 directly in lung cancer cells

Chen-Chu Lin et al.

Summary: The study suggests that miR-10b may function as an upstream regulator of p53 and contribute to the development and treatment resistance of lung cancer by affecting p53 expression and signaling pathways. The expression levels of miR-10b are closely associated with the prognosis of patients with lung cancer, indicating a novel oncogenic role of miR-10b in non-small cell lung carcinoma.

ONCOLOGY REPORTS (2021)

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Article Oncology

Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression

Yi Shen et al.

Summary: Our study found that abnormal expression of miR-10b in digestive system cancers is associated with poor prognosis, especially in colorectal cancer, gastric cancer, hepatocellular carcinoma, and esophageal carcinoma. Target genes of miR-10b are mainly enriched in pivotal signaling pathways related to tumor progression, such as cell cycle, FoxO, Notch, etc.

JOURNAL OF CANCER (2021)

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Article Cardiac & Cardiovascular Systems