4.5 Article

Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine

Related references

Note: Only part of the references are listed.
Article Virology

Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity

Ramona Dolscheid-Pommerich et al.

Summary: This study analyzed the correlation between binding IgG and neutralizing antibodies in COVID-19 patients, revealing a strong positive relationship and supporting the use of QuantiVac ELISA to assess protective immunity post-infection or vaccination.

JOURNAL OF MEDICAL VIROLOGY (2022)

Article Immunology

Cross-protective immunity of the haemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice

Han Lei et al.

Summary: The study demonstrated that oral administration of recombinant L. lactis/pNZ8150-pgsA-HAsd in mice generated cross-protection against H5N1, H3N2, and H1N1 viruses. These findings suggest that the expression of HAsd on the surface of L. lactis may provide cross-protective immunity against divergent influenza A viruses, offering a promising alternative approach for developing a novel universal vaccine during an influenza A pandemic.

VIRULENCE (2021)

Editorial Material Microbiology

The great escape? SARS-CoV-2 variants evading neutralizing responses

Jeremie Prevost et al.

Summary: The articles highlight the importance of surveillance of SARS-CoV-2 evolution to anticipate and manage new variants that could impact reinfection, vaccine efficacy, and immunotherapies.

CELL HOST & MICROBE (2021)

Article Multidisciplinary Sciences

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Hyon-Xhi Tan et al.

Summary: The study compared the immunogenicity of spike proteins (S) and receptor binding domain (RBD) in SARS-CoV-2 vaccines in mice and macaques, finding that S was highly immunogenic in mice while RBD was comparatively poor. Both S and RBD vaccines were similarly immunogenic in macaques, inducing serological neutralising activity exceeding convalescent human levels.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Yinon M. Bar-On et al.

Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Oral delivery of maize-produced porcine epidemic diarrhea virus spike protein elicits neutralizing antibodies in pigs

Erin Egelkrout et al.

PLANT CELL TISSUE AND ORGAN CULTURE (2020)

Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

Article Biochemistry & Molecular Biology

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Quan-Xin Long et al.

NATURE MEDICINE (2020)

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Comparative immunogenicity of preparations of yeast-derived dengue oral vaccine candidate

Jyotiranjan Bal et al.

MICROBIAL CELL FACTORIES (2018)

Review Microbiology

Polio vaccination: past, present and future

Ananda S. Bandyopadhyay et al.

FUTURE MICROBIOLOGY (2015)

Review Immunology

Current advancements and potential strategies in the development of MERS-CoV vaccines

Naru Zhang et al.

EXPERT REVIEW OF VACCINES (2014)

Article Biotechnology & Applied Microbiology

Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune responses in mice

Liu Hongli et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

Article Medicine, Research & Experimental

Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein

Dharmendra Raghuwanshi et al.

MOLECULAR PHARMACEUTICS (2012)

Article Pharmacology & Pharmacy

Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles

Olga Borges et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)

Article Infectious Diseases

The SARS-CoV nucleocapsid protein: A protein with multifarious activities

Milan Surjit et al.

INFECTION GENETICS AND EVOLUTION (2008)

Article Immunology

B subunit of E-coli enterotoxin as adjuvant and carrier in oral and skin vaccination

E. Fingerut et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2006)