Journal
VACCINE
Volume 40, Issue 13, Pages 1924-1927Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2022.02.052
Keywords
Reactogenicity; Spike IgG titer; SARS-CoV-2; Fever; BNT162b2 vaccine
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Funding
- Abbott Japan [20C050]
- NCGM COVID-19 Gift Fund [19K059]
- Japan Health Research Promotion Bureau Research Fund [2020-B-09]
- National Center for Global Health and Medicine [21A006]
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The study observed that high vaccine reactogenicity after COVID-19 vaccination may be associated with stronger immune responses, and found a correlation between fever after vaccination and higher levels of SARS-CoV-2 spike antibodies.
High vaccine reactogenicities may reflect stronger immune responses, but the epidemiological evidence for coronavirus disease 2019 (COVID-19) vaccines is sparse and inconsistent. We observed that a fever of >38celcius after two doses of the BNT162b2 vaccine was associated with higher severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike IgG titers. (c) 2022 Elsevier Ltd. All rights reserved.
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