Journal
TRENDS IN PARASITOLOGY
Volume 38, Issue 1, Pages 11-14Publisher
CELL PRESS
DOI: 10.1016/j.pt.2021.10.005
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Funding
- Wellcome Trust [220211, 223253/Z/21/Z]
- Royal Society [223253/Z/21/Z]
- Wellcome Trust [223253/Z/21/Z] Funding Source: Wellcome Trust
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Balancing selection maintains equilibrium allele frequencies of hemoglobin S between 15% and 20% in areas of high Plasmodium falciparum transmission, driven by the malaria-protective effect of sickle-cell trait. Based on this, malaria-attributable childhood mortality in the pretreatment era is estimated to be between 15% and 24%.
Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
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