Journal
TRENDS IN PARASITOLOGY
Volume 38, Issue 4, Pages 274-276Publisher
CELL PRESS
DOI: 10.1016/j.pt.2022.02.001
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Funding
- NSERC -Natural Sciences and Engineering Research Council of Canada [RGPIN-201704480]
- CIHR -Canadian Institutes of Health Research Project Grant [PJT-173450]
- Canada foundation for Innovation (CFI) [37324, 38858]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/09948-0]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [424729/2018-0]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais -Fapemig [PPM-00699-18]
- CNPq [CNPq: 314103/2021-0, 312965/2020-6]
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Recently, it has been discovered that induced DNA damage in axenic culture facilitates genetic exchange in Leishmania hybrids, leading to the formation of full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 play a crucial role in this process, opening up new avenues for functional genomic studies.
The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies.
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